PPARG and esophageal squamous cell carcinoma: By integrating transcriptomic and lipid metabolomic profiling, a large number of fatty acids and lipid mediators are pan-agonists of peroxisome proliferator-activated receptors (PPARs), and arachidonic acid, unsaturated fatty acid, significantly affects esophageal squamous cell carcinoma by regulating peroxisome proliferator-activated receptor gamma (PPARg) and OXPHOS M2 polarization in macrophages [165].