CXCL8 and esophageal adenocarcinoma: As indicated by Lim Kee et al., the deoxycholic acid (DCA) also stimulated the production of interleukin-6 (IL-6) and interleukin-8 (IL-8) in esophageal adenocarcinoma cells via raft-related signaling, thus facilitating esophageal metaplasia and dysplasia [188].