Compared to aCL negative patients there was no difference in disease severity (p = 0.505), outcome (p = 0.635), or relevant laboratory parameters [aPTT (p = 0.492), D-dimer (p = 0.292), CRP (p = 0.423), ferritin (p = 0.202), IL-6 (p = 0.336), SII (p = 0.243)].There were 8 (15.7%) thrombotic events during COVID-19 (7 pulmonary thromboembolism, 1 acute myocardial infarction), but they were not associated with aCL positivity (p = 0.668). This evidence concerns the gene IL6 and COVID-19.