PANDAS: pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; ASO: antistreptolysin O; anti-DNase B: antideoxyribonuclease-B antibody; MRI: magnetic resonance imaging [3,36,44]. The gene discussed is CRP; the disease is streptococcal infection.