MMP3 and Anxiety: For example, inflammatory cytokine/chemokine levels were found to be associated with anxiety, depression and memory impairment in METH users, and the immune factors CRP (C-reaction protein), IL-8, MMP-3, SCF, VEGF, eotaxin-1 and IL-23 were significantly correlated with the anxiety symptoms induced by METH (Huckans et al., 2015).