The first generation STING agonist, 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA), was originally developed as a vascular-disrupting agent (218, 219) and its anti-tumour effect is based on vascular necrosis leading to tumour starvation and haemorrhagic necrosis (218, 220). The gene discussed is STING1; the disease is neoplasm.