In terms of DNA-PKcs inhibition leading to stimulation of the innate immune system, a recent study showed that combining radiation with M3814-induced DNA-PK inhibition increased cytosolic dsDNA and tumour type I interferon signalling in a cGAS-STING-independent, but RNA Polymerase III-, RIG-I- and MAVS-dependent manner, in pancreatic cancer models (91). The gene discussed is PRKDC; the disease is familial pancreatic carcinoma.