Promising preclinical in vivo studies (Table 1) of the ATR inhibitor ceralasertib (AZD6738) in combination with radiotherapy have shown an enhanced type I/II interferon response and increased immune cell infiltrate (88), increased RT-stimulated CD8+ T cell infiltration (87, 89), NK-mediated anti-tumour immunity (90), as well as reversal of the Treg immunosuppressive effect (87, 89). Here, CD8A is linked to neoplasm.