The U.S. Food and Drug Administration approved anti-CD19 CAR-T cell therapy Tisagenlecleucel for the treatment of B-cell acute lymphoblastic leukemia (ALL) (7), ADC drug Loncastuximab Tesirine-Lpyl for the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) (8) and PD-1 inhibitor Pembrolizumab for the treatment of Hodgkin lymphoma (9). This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.