Once targeting S1P or inhibiting SK1, the killing effect of NK cells can be restored on MCL cells, and accompanied by the up-regulation of cardiolipin, phosphatidylcholine, phosphatidylethanolamine and sphingomyelin, especially the up-regulation of cardiolipin suggests that cardiolipin induce the activation of NK cells. Here, MBTPS1 is linked to mantle cell lymphoma.