CD8A and neoplasm: ARGcluster A is usually identified as “hot” tumors characterized by strong immune infiltration levels that will benefit more from the immunotherapy, while ARGcluster B can be characterized as a “cold” tumor with low intensity of immune infiltration and relatively unsuitable for immunotherapy. Furthermore, we explore the correlation between known biological processes and these two ARGclusters, where some immune-related processes like CD8 T effector, antigen processing machinery, and Pan−F−TBRS were prominent in ARGcluster A (Figure 3K).