Some recent evidence has revealed that MTBP can function as a pro-proliferative and oncogenic regulator in human malignancies by some potential mechanisms (16–20): MTBP may promote the proliferation of cancer cells by function as a co-amplified of c-MYC, which is a typical oncogene, or ZEB2, one of the key regulators of the epithelial–mesenchymal transition (EMT) process (16–20, 75–77). This evidence concerns the gene ZEB2 and cancer.