Although it is well known that HCC is related to aberrant activation of receptor tyrosine kinases (RTKs) or RTK-activated intracellular cascades (mitogen-activated protein kinase [MAPK] or phosphoinositide-3-kinase/protein kinase B [PI3K/AKT]), the genetic alterations related to the tumorigenesis, metastasis, and/or progression of HCC remains poorly understood and the in-depth research work is a necessity (7–10). The gene discussed is WNK2; the disease is hepatocellular carcinoma.