Intriguingly, the gene encoding pogo transposable element-derived protein with zinc-finger domain (POGZ), an interacting partner of CHAMP1, is also mutated in individuals with ID, as well as in individuals with ASD,18–21 causing a variety of phenotype known as White-Sutton syndrome.22 The POGZ mutations found in ID are either nonsense or frameshift de novo mutations similar to CHAMP1 mutations. This evidence concerns the gene POGZ and white-sutton syndrome.