STING1 and enterocolitis: Louie et al. (2020) explored the in vivo role of the STING pathway during bacterial pathogenesis and found that STING activation led to a reduced bacterial burden and correlated with the recruitment of monocytes to the intestines during L. monocytogenes-induced enterocolitis. This STING-mediated protective response was triggered by the c-di-AMP secretion of L. monocytogenes, while the disruption of type I IFN signaling did not recapitulate STING deficiency.