PKD1 and Other metabolic disease: As an additional link between kidney inflammation and metabolic disease, LKB1 forms a complex with PC1 to suppress the expression of MCP-1 in tubular epithelia; the tubular deletion of Lkb1 or Pkd1 restores MCP-1 expression and causes monocyte/CCR2+ macrophage recruitment (Viau et al., 2018).