The network comprising PPARα and its gene targets is known to be downregulated in mouse models of ADPKD and human cysts, and PPARα downregulation is in part responsible for the intrinsic defect in fatty acid oxidation seen in ADPKD (Hajarnis et al., 2017; Lakhia et al., 2018; Lakhia, 2020). The gene discussed is PPARA; the disease is autosomal dominant polycystic kidney disease.