In humans, increased circulating MCP-1 correlates with higher levels of other inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6), but also obesity, waist circumference, and the homeostatic model assessment for insulin resistance (HOMA-IR) score (Kim et al., 2006). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.