Similar to these studies in colon cancer models, cell adhesion in the HCC cell line H22 via α5β1 integrin required α2,6 sialylation (Yu et al., 2013) and ST6Gal1-mediated hypersialylation of integrin β1 resulting in increased attachment to collagen I was determined in ovarian carcinoma (Christie et al., 2008). This evidence concerns the gene ST6GAL1 and colonic neoplasm.