ST6GAL1 and familial pancreatic carcinoma: Furthermore, in a Genetically Engineered Mouse Model (GEMM) of pancreatic cancer with RAS activation via expression of K-RasG12D under the control of p48Cre (Qian et al., 2009), the loss of ST6Gal1 resulted in normal acinar area and decreased fibrosis (Kurz et al., 2021).