While a pro-migratory and invasive phenotype of ST6Gal1 mediated by β1 sialylation is often determined, this is not always the case: ST6Gal1 knockdown increased metastasis as well as expression of integrin α3β1 in the metastatic CRC cell line SW620 (Jung et al., 2016). Here, ST6GAL1 is linked to colorectal carcinoma.