TNFRSF1A and rectal cancer: Similarly, ST6Gal1 is reported to directly α2,6 sialylate TNFR1 and block the TNFα-induced apoptotic pathway in macrophages (Liu et al., 2011a), rectal cancer (Smithson et al., 2022), and pancreatic and ovarian cancer (Holdbrooks et al., 2018).