Elevated Wnt signaling, including via increased expression of regulators like WNT3A and β-catenin, was identified in RNA-sequencing analysis of metastatic subclones of pancreatic cancer cell lines S2-LM7AA and S2-013 that expressed high levels of ST6Gal1 (Britain et al., 2021). Here, ST6GAL1 is linked to familial pancreatic carcinoma.