In the same cancer model, ST6Gal1 activated β1-integrin, further enhancing attachment to collagen and laminin: this resulted in heightened motility and highlighted the importance of ST6Gal1-regulated β1 integrin in disease progression and migration (Seales et al., 2005b; Chiricolo et al., 2006). The gene discussed is ST6GAL1; the disease is cancer.