Examples of those genes include NDRG1, which regulates TH2 differentiation, a key driver in asthmatic disease, downstream of the mTORC2 complex (Murray et al., 2004; Heikamp et al., 2014), ADAM17, a metalloproteinase involved in lung inflammation (Dreymueller et al., 2015), PIEZ O 1, a mechanosensor regulating T cell activation (Liu et al., 2018) and pulmonary inflammatory responses (Solis et al., 2019), and the P-selectin ligand encoding gene SELPLG, important for recruitment of lymphocytes to the airways (Leath et al., 2005; Purwar et al., 2011). The gene discussed is ADAM17; the disease is inflammation.