NEAT1_2 is induced by various stressors and pathological conditions, such as proteasome inhibition, viral and microbial infections, neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), fibrosis, and cancer/p53 activation (Nishimoto et al., 2013; Hirose et al., 2014) (Tollervey et al., 2011; Tsuiji et al., 2013; Imamura et al., 2014; Adriaens et al., 2016; Idogawa et al., 2017; Imamura et al., 2018; Fukushima et al., 2020; Rheinbay et al., 2020). This evidence concerns the gene TP53 and amyotrophic lateral sclerosis.