NLRP3 and obesity due to melanocortin 4 receptor deficiency: Protection against obesity was associated with carrying the G/A genotype (ORadj = 0.42 [95% CI, 0.23-0.78], P = 0.006) or carrier-A (ORadj = 0.48 [95% CI, 0.27-0.85], P = 0.012) in the NLRP3 rs3806268 polymorphisms, whereas a slightly increased risk for obesity was observed for those carrying the A allele in the NLRP3 rs35829419 polymorphism (ORadj = 1.21 [95% CI, 1.02-1.44], P = 0.029) (Table 4S).