Although COVID-19 has an important inflammatory profile [83] and constitutive increases in pro-IL-1β contribute to the cytokine storm that worsens the clinical status of patients [84], in our study, we found that the allele T, carrier-T, or genotype A/T in CARD8 rs2043211 polymorphisms is associated with protection against disease severity in individuals infected with SARS-CoV-2. The gene discussed is CARD8; the disease is COVID-19.