We also found that carrier-C in the NLRP3 rs1539019 polymorphism and the G/A genotype of the NLRP3 rs3806268 polymorphism were associated with protection against diabetes mellitus and obesity, respectively; on the other hand, carrying the A allele in the NLRP3 rs35829419 polymorphism was associated with a risk of obesity. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.