NLRP3 has been linked to the pathogenesis of several diseases, including [1] metabolic disorders, such as type 2 diabetes [64], obesity [65], and autoimmune and inflammatory diseases [66–68]; neurological diseases [69]; and [2] diseases caused by viral pathogens, such as HIV [50], influenza A [70], and SARS-CoV [71]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.