TLR4 and ischemic stroke: Electroacupuncture (EA) regulates downstream effectors of the TLR4/NF-κB signaling pathway, such as reducing the secretion of inflammatory factors such as TNF-α, interleukin-1 (IL-1), and IL-6 and effectively reducing pneumonia [27] and brain ischemic inflammatory response [28], and it plays a neuroprotective role in ischemic stroke [29].