DLS: Dutch Leakage Score, CRP: C-Reactive Protein, PCT: Procalcitonin, AL: Anastomotic Leak, LAR-TME: Low Anterior Resection -Total Mesorectal Excision, POD: Post Operative Day, CCL8/MCP-2: Chemokine C-C motif ligand 8/Monocyte Chemotactic Protein-2, LIF: Leukotriene Inhibitory Factor, CXCL5/ENA-78: C-X-C motif chemokine 5/Epithelial Neutrophil -Activating Peptide, WCC: White Cell Count, BT: Body Temperature, CRC: Colorectal Cancer. The gene discussed is CCL8; the disease is colorectal carcinoma.