The NFKB1 variants, which showed only a minor functional defect or for which no defect could be specified, were identified in patients with CVID (n=11), antibody deficiency (n=6), autoinflammatory disorder (n=2), CID (n=1) or in unaffected individuals (n=4). The gene discussed is NFKB1; the disease is agammaglobulinemia.