The overall profile of plasma chemokines (CCL11, CXCL8, CCL3, CCL4, CCL2, CCL5, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-15, IL-17), regulatory cytokines (IL-1Ra, IL-4, IL-5, IL-9, IL-10, IL-13), and growth factors (FGF-basic, VEGF, PDGF, G-CSF, GM-CSF, IL-7, and IL-2) was characterized on D28 and D28* upon COVID-19 vaccination with a half dose compared to the full dose. This evidence concerns the gene IL10 and COVID-19.