IL1B and obesity due to melanocortin 4 receptor deficiency: Interestingly, IL-1β signalling, a key factor in driving the pathogenic transformation of synovial fibroblasts in CIA and rheumatoid arthritis that is targeted by ES-62 (65), is crucial to the pro-inflammatory training of both BM and migratory “surveillance” haemopoietic stem and progenitor cells (HSCPs) and their resultant accumulation and differentiation into adipose tissue-resident myeloid cells that perpetuates the inflammatory osteoimmunology cycle in obesity (24, 66–68).