Experiments involving additional d340 cohorts of PBS-Chow-, ES-62-Chow- and, as an obesity-accelerated ageing control, PBS-HCD-fed mice, showed that treatment with ES-62 had no effect on the levels of these adipose CD11c+ macrophages or Bregs in either male Chow-fed mice (Figures 6M, N). The gene discussed is ITGAX; the disease is obesity disorder.