Percentage of seroconversion was 87.5% in DM patients with monotherapy, 68.6% and 93.3% and 81.2% in those with combination therapy, 100% among patients on insulin and 60% and 80% among DM patients with no medication, after first and second dose respectively. There was no statistically significant difference between the subgroups. The gene discussed is INS; the disease is diabetes mellitus.