IGF1R and Graves disease: In addition to solid tumours and haematological malignancy, antibodies against IGF1R are currently in clinical trials for patients with autoimmune ophthalmopathy related to the Grave’s disease (26, 65), and other thyroid eye diseases (NCT01868997, NCT04583735), diabetic macula oedema (NCT02103283) and diffuse cutaneous systemic sclerosis (NCT04478994).