Sickle cell disease (SCD) is a chronic hemolytic illness characterized by the generation of aberrant hemoglobin, which affects hemoglobin (Hb) molecule stability during hypoxemia with the stacking of abnormal Hb onto monofilaments and ultimately forms unique sickle cells, resulting in increased hematic viscosity, hemolysis, and microvascular blockage [1]. The gene discussed is GSTM1; the disease is Schnyder corneal dystrophy.