Sickle cell disease (SCD) is a chronic hemolytic illness characterized by the generation of aberrant hemoglobin, which affects hemoglobin (Hb) molecule stability during hypoxemia with the stacking of abnormal Hb onto monofilaments and ultimately forms unique sickle cells, resulting in increased hematic viscosity, hemolysis, and microvascular blockage [1]. Here, GSTM1 is linked to sickle cell disease.