While characterizing the activation status of CD8+ T cell, we found at least a 10-fold increase in the effector phenotype (CD44+) and a concomitant decrease in the naïve phenotype (CD62L+) that was evident on the 8th day of infection and with no apparent difference between WT and Cd47−/− mice (Figure 5d,e). The gene discussed is SELL; the disease is infection.