CTLA4 and fungal infectious disease: Candida albicans fungal infection, on the other hand, showed increased morbidity and mortality of Cd47−/− mice due to wider dissemination of infection along with elevated neutrophil, macrophage and CD4 + T cell infiltrates, and increased inflammatory cytokine levels.67 Treatment of mice infected with Ebola virus with the function blocking CD47 miap301 adversely affected survival with increased inflammatory cytokine responses, B cell activation, and CTLA4+ CD8+ and CD4 + T cells.