Similarly, CD47 inhibited the differentiation of naïve to effector CD4 T cells.77 Blocking CD47 by a monoclonal antibody or antisense knockdown, therefore, enhanced the anti-tumor function of CD8+ T cells as reported in multiple studies.19,21,30 Depletion of Cd47−/− CD8+ T cells in the tumor-bearing mice is consistent with an enhanced contraction and differentiation which is further supported by the expression of differentiated central memory marker CD127. This evidence concerns the gene CD4 and neoplasm.