Next, we filtered 2,364 shared genes that were at least 1.5-fold differentially expressed upon 6 h activation in WT versus Cd47−/− CD8+ T cells (Data S3) and compared them with transcriptional profiles identified in pathogen-reactive CD8+ T cells.41 Those authors selected 1,487 genes that had a difference in expression of at least twofolds in response to Listeria monocytogenes (Lm-OVA) infection and clustered into 10 unbiased groups with the most dynamic patterns according to kinetic patterns of expression (by K-means clustering). This evidence concerns the gene CD8A and infection.