Lim et al. reviewed how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes (TIL).108 CD28 co-stimulation can greatly enhance CD8+ TIL metabolism and function through the rescue of T cell glycolysis that supports mitochondrial mass and activity.109 CD47 clearly plays a role in CD8+ TIL function. This evidence concerns the gene CD8A and neoplasm.