CD8A and neoplasm: Similarly, CD47 inhibited the differentiation of naïve to effector CD4 T cells.77 Blocking CD47 by a monoclonal antibody or antisense knockdown, therefore, enhanced the anti-tumor function of CD8+ T cells as reported in multiple studies.19,21,30 Depletion of Cd47−/− CD8+ T cells in the tumor-bearing mice is consistent with an enhanced contraction and differentiation which is further supported by the expression of differentiated central memory marker CD127.