CD8A and infection: LCMV infection is an excellent model to study both short- and long-term immune responses of CD8+ T cells.59 LCMV-Armstrong (Arm) causes an acute infection that clears within a week of infection, whereas the LCMV clone 13 (Cl13) causes chronic infections that persist for months post-infection.78 The dynamics of CD8+ T cell responses during acute and chronic LCMV infection are unique.