CD8A and melanoma: In our earlier studies, we observed elevated growth of B16F10 melanoma tumors in Cd47−/− mice, which was partly due to depleted NK cell population.29 However, looking at the T cell compartment and on day 15 post tumor implantation, we also observed significant reduction of the CD8+ T cells in the spleen and within the tumor infiltrating lymphocytes (TILs).