SSPOP and scoliosis: As an alternative explanation to the etiopathogenesis of scoliosis, investigations of ptk7a and sspo IS models implicate neuroinflammatory and oxidative stress responses that arise downstream of CSF homeostasis defects as necessary and sufficient to drive spinal curvature (Van Gennip, Boswell and Ciruna, 2018; Rose et al., 2020).