SHH and microlissencephaly: Based on human KATNB1 mutations linked to microlissencephaly, studies utilizing cell culture and mouse models also revealed the functional importance of KATNB1 in centriole biogenesis, Shh signaling, and neural progenitor development (Hu et al., 2014; Mishra-Gorur et al., 2014), whereas analysis of maternal-zygotic (MZ) katnb1 mutant zebrafish demonstrated a critical role for Katnb1 in early embryonic patterning and viability (Hu et al., 2014).