Additionally, they can suppress angiogenesis by inhibiting the secretion of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 2 (VEGFR2), and kinase insert domain receptor (KDR)/flk-1 in tumors, as well as affecting different signaling pathways and transcription factors related to tumor growth [161, 162]. This evidence concerns the gene KDR and neoplasm.