4112 genes highly associated with the HBV-HCC transformation model were identified (|r| > 0.5, p < 0.05), and 293 genes whose CERES scores closely associated with the HBV-HCC transformation model were identified (r < −0.5, p < 0.05), and 907 shared genes before TP53 cluster during the formation of LCC in subtype 1 patients were identified. This evidence concerns the gene TP53 and hepatocellular carcinoma.