In a study exploring the effect of sericin on diabetic nephropathy (DN) in rats, the results depicted that sericin treatment evidently relieved renal pathological changes, decreased the p-p38MAPK inflammatory signaling pathway, which can regulate the inflammatory response of the kidney, and inhibited the activation of NLRP3 inflammasome which possesses a crucial role in DN occurrence and development [56]. The gene discussed is NLRP3; the disease is liver dysplastic nodule.