Consistent with this, in this experiment, after the E6 and E7 genes of HPVl6 and HPVl8 viruses were silenced, respectively, the expression of cadherin and the marker of EMT increased, while the expression of N-cadherin and b-catenin decreased; that is, the process of mesenchymal epithelial transformation occurred, the degree of tight junction between cells increased, and the ability of migration decreased, that is, the capacity of tumor cells to invade, infiltrate, and metastasize decreased [34, 35]. This evidence concerns the gene CDH2 and neoplasm.