Moreover, IGF-I and -II, their receptors, and several IGF-binding proteins (IGFBP-2, -3, -4, -5) are overexpressed in glioblastoma compared with normal brain tissue or low-grade glioma; this overexpression is associated with poor prognosis or less favorable responses to therapy (30). The gene discussed is IGFBP2; the disease is glioblastoma.