In LP42 and SPLP42, the most interesting pathways were those associated with reproduction (Oocyte meiosis, MAPK signaling pathway, and Dopaminergic synapase, as shown in Figure 6A), and pathways associated with the disease were also enriched (cGMP-PKG signaling pathway, Kaposi sarcoma-associated herpesvirus infection, VEGF signaling pathway and Pathways in cancer). The gene discussed is VEGFA; the disease is cancer.