We performed univariate Cox regression to examine the prognostic value of 55 pyroptosis-related genes in PCa and identified twelve pyroptosis-related genes that predicted RFS: CASP8, GSDMB, BAK1, BAX, CHMP4B, CHMP4C, CHMP6, TP53, TP63, CASP9, GPX4 and PLCG1 (P<0.1, Supplementary Table S3). This evidence concerns the gene CASP8 and posterior cortical atrophy.