Not only does NAFLD increases the risk of liver fibrosis, liver cirrhosis and hepatocellular carcinoma, but it also is closely related to obesity, abnormal lipid metabolism and decreased insulin sensitivity, which leads to extrahepatic complications such as type 2 diabetes, cardiovascular diseases and cerebrovascular diseases, and so on (2–4). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.