MGMT and glioblastoma: —FoxD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is a lncRNA highly expressed in recurrent GBM tumors and is associated with decreased patient survival.45 A study showed that suppression of FOXD2-AS1 via a small interfering RNA (siRNA) is associated with decreased GBM cell viability in TMZ.16 While the specific mechanism is unclear, the study reported that FOXD2-AS1 may oppose TMZ cytotoxicity through MGMT upregulation.