As a relatively newly discovered lncRNA, linc00174 is markedly upregulated in human GBM tissues and its expression level is inversely correlated with patient survival rate.25Linc00174 has been reported to strengthen TMZ resistance in GBM cells by directly targeting miR-138-5p, a tumor suppressive miRNA shown to arrest GBM cell cycle.69 By inhibiting miR-138-5p, linc00174 increases SRY-Box Transcription Factor 9 (SOX9), a downstream target of miR-138-5p. Here, SOX9 is linked to glioblastoma.