SOX2 and central nervous system cancer: LncRNA SOX2 overlapping transcript (SOX2OT) is mapped to the human chromosome 3q26.3 and harbors the SRY-Box Transcription Factor 2 (SOX2) gene in its intronic region.60 Analysis of patient-derived GBM samples has shown SOX2OT level to positively correlate with both advanced glioma grade and reduced median survival time.61 In vitro studies showed that GBM cells U87 and U251 transfected with SOX2OT siRNA lentiviral vectors (si-SOX2OT) displayed increased TMZ-mediated apoptosis.