MGMT and cancer: Studies have previously focused on well-recognized contributors to TMZ resistance including O6-methylguanine-DNA methyltransferase (MGMT) DNA damage response (DDR), MMR defects, as well as presence of cancer stem cells, and tumor hypoxia.5–8 However, it has been increasingly recognized that long non-coding RNAs (lncRNAs) play an extensive role in mediating various aspects of GBM pathology, including the chemoresistance mechanisms described here.