EPHA8 and central nervous system cancer: Furthermore, the authors determined that RP11-838N2.4 level is inversely associated with miR-10a, which negatively regulates its downstream target, ephrine tyrosine kinase receptor A8 (EphA8).30 Prior data has shown enhanced EphA8 reverses EMT and transforms glioma cells to the more cobble-stoned appearance of epithelial cells.