SBF2-AS1, which is upregulated in TMZ-resistant GBM cells, functions as a ceRNA against miR-151a-3p to enhance X-ray repair cross-complementing 4 (XRCC4) protein levels, augmenting DSB repair in gliomas.20 Radiation-induced DNA damage can similarly activate lncRNAs. Here, XRCC4 is linked to central nervous system cancer.