In GBM, lncRNA P73 antisense RNA 1T (TP73-AS1) expression level is elevated in patient-derived GSCs and correlates directly with early mortality.21 Mazor et al. used CRISPR to downregulate TP73-AS1 in two established human GSC lines and noted that the cells exhibited decreased viability under TMZ treatment. The gene discussed is TP73; the disease is glioblastoma.