In contrast, loss of EphA8 is associated with shorter survival time, and diminished TMZ response in GBM patients.81 Further mRNA and protein analysis indicated that RP11-838N2.4 reduces the expression of miR-10a and relieves its inhibitory effect on EphA8, resulting in enhanced TMZ cytotoxicity by decreasing the EMT process. Here, EPHA8 is linked to glioblastoma.