These include the H3K27M oncohistone mutation that occurs in diffuse midline gliomas, or expression of the gonad specific PRC2 subunit EZHIP in ependymoma (Sturm et al., 2012; Wu et al., 2012; Lewis et al., 2013; Pajtler et al., 2018). Here, EZHIP is linked to diffuse midline glioma.