Recent studies have shown that PR-DUB and the catalytic function of BAP1 are required for maintenance of PRC2 target gene occupancy and PcG-mediated repression in ESC and cancer cells (Scheuermann et al., 2010; Abdel-Wahab et al., 2012; Conway et al., 2021; Fursova et al., 2021). This evidence concerns the gene BAP1 and cancer.