For instance, in Ewing sarcomas expressing the oncogenic transcription factor EWSR1-FLI1, RING1B colocalizes with EWSR1-FLI1 at active enhancers to regulate its recruitment to chromatin and promote transcription (Figure 4A) (Sánchez-Molina et al., 2020). This evidence concerns the gene FLI1 and Ewing sarcoma.