BAZ2A (bromodomainadjacent to zinc finger domain protein 2A) isone of the nucleolar remodeling complexes mediating chromatin condensationand silencing of ribosomal DNA (rDNA).3,4 However, itsrole extends beyond the epigenetic modulation of rDNA transcription.In prostate cancer, BAZ2A is overexpressed and cooperates with EZH2(enhancer of zeste homolog 2) in potentiating tumor cells’migration and metastatic potential.5,6 BAZ2A has thenbeen proposed as a prognostic marker for aggressive and recurrentprostate cancer as well as a promising therapeutic target. The gene discussed is EZH2; the disease is cancer.