Some of these RBCs systems such as the Gardos channel, K-Cl cotransporter, and the Na/K pump are directly involved in the maintenance of RBC hydration; their increased activity contributes to RBC dehydration in SCD subjects (Vitoux et al., 1989; Gibson et al., 1998; Izumo et al., 1987; Luthra and Sears 1982; Hannemann et al., 2015). This evidence concerns the gene KCNN4 and Schnyder corneal dystrophy.