CD274 and neoplasm: Faustino et al. showed that, in OSCC, the presence of CD68+ and CD163+TAMs is associated with the high PD-L1 levels, which binds to the PD-1 receptor on the surface of activated-T cells and transmits inhibitory signals to T cells.This prevents the immune system from attacking tumor cells and enables these cells to obtain the ability to escape the immune system (Schmid et al., 2018; Kelly et al., 2019.; Suarez-Sanchez et al., 2020).