In the TME, TAMs participate in tumor angiogenesis by releasing growth factors such as CCL2, CXCL8, CXCL12, EGF, IL-1β, IL-8, PIGF, TGF-β, and VEGF-A (Wyckoff, 2004; Chen et al., 2011; Tang et al., 2017; Yang et al., 2019). Here, EGF is linked to neoplasm.