After reaching the leading edge of tumor progression, TAMs can promote tumor cells motility and hydrolytic remodeling of the extracellular matrix (ECM) by secreting epidermal growth factors (EGFs) and other pro-migration factors and regulating the production of collagen fibers to enhance tumor cells invasion (O'Sullivan et al., 1993; Singh et al., 2010). The gene discussed is EGF; the disease is neoplasm.