Likewise, increased evidence has also been pointed out the role of IL-6, a biomarker of OSA, in mediating connections among OSA, IR or Mets (Kim et al., 2009; Maeder et al., 2015; Akbari and Hassan-Zadeh, 2018; Motamedi et al., 2018; Ko et al., 2019; Imani et al., 2020; Campos-Rodriguez et al., 2021), Although the molecular mechanisms are not clear, our findings indicate that these clocks / oxidative stress / inflammation / IR interactions play a key role in the linkage between OSA and MetS. This evidence concerns the gene IL6 and obstructive sleep apnea syndrome.