König et al. (2021) found that activation of TNF was dependent on IL6 signaling, and TNF also limited the action of IL1B. Furthermore, activation of IL6 transsignal must be “downstream” of TNF signaling (König et al., 2021). Meanwhile, IL1B is highly expressed NF-κB activator in triple negative breast cancer (TNBC) (Ignacio et al., 2019). NF-κB can increase the expression of TNF-α and IL6 (Huang et al., 2008; Liu et al., 2013). Therefore, IL1B and TNF-α can regulate each other. And You et al. (2021) demonstrated that IL1B enhanced the expression level of CXCL8 in TNBC cells. The gene discussed is TNF; the disease is triple-negative breast carcinoma.