Moreover, it has been demonstrated that cardiomyocyte-specific knockout of Akap6 in mice or knockdown of Akap6 by siRNA in cardiomyocytes has protective effects against corresponding TAC-induced cardiac hypertrophy and heart failure or ISO-triggered cardiomyocyte hypertrophy (Pare et al., 2005; Kritzer et al., 2014). This evidence concerns the gene AKAP6 and heart failure.