Urinary exosomal miR-30c-5p also appeared to be a potential diagnostic biomarker for early ccRCC, and miR-30c-5p overexpression was shown to inhibit ccRCC progression in vitro and in vivo by targeting heat-shock protein 5 (HSPA5) (Song et al., 2019). Here, HSPA5 is linked to nonpapillary renal cell carcinoma.