NFKB1 and Sepsis: In the kidneys, up-regulated exosomal miR-21 enters RTECs and then targets the downstream PDCD4/NF-κB and PTEN/AKT pathways, exerting anti-inflammatory and anti-apoptotic effects both in vivo and in vitro, thereby reducing sepsis-induced renal injury (Pan et al., 2019).