The inflammatory cascade reaction mediated by neutrophil granulocyte and mononuclear macrophages is one of the common mechanisms leading to the myocardial fibrosis, which can secrete a variety of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6, leading to the myocardial fibrosis. Here, IL1B is linked to Myocardial fibrosis.