The tablet of oral dapagliflozin (a SGLT2 inhibitor) has been approved by the Food and Drug Administration (FDA) used for the treatment of heart failure on May 5, 2020 (CAS registration no. 461432-26-8), mainly for the heart failure patients with reduced ejection fraction, which is aimed at reducing the risk of cardiovascular mortality and admission due to heart failure of patients. This evidence concerns the gene SLC5A2 and heart failure.