According to the results of the western blotting analysis (Figures 9, 10), the level of AKT, p-AKT, CREB, and p-CREB of the CRS group were lower than the control group (F4,10 = 4.721, F4,10 = 2.160, F4,10 = 3.832, F4,10 = 5.039, p < 0.05, p < 0.05, p < 0.001, p < 0.05), and the expression of Cyt C, DrP1, and BAX in the hippocampus of CRS-induced mice were significantly higher than the control group (F4,10 = 5.54, F4,10 = 4.164, F4,10 = 10.863, p < 0.01, p < 0.05 and p < 0.01, respectively). This evidence concerns the gene AKT1 and congenital rubella syndrome.