The GSH depletion induce many cancer cells to ferroptosis, such as pancreatic tumor (Badgley et al., 2020), liver cancer (Chen et al., 2019; Yang Y. et al., 2020), prostate cancer (Qin et al., 2021), breast cancer (Yang J. et al., 2021) etc. It is also possible to produce an effect similar to GPX4 inactivation by inhibiting the GSH synthesis or antagonizing GSH. The gene discussed is GPX4; the disease is breast cancer.