GPX4 and colorectal cancer: In addition, inhibiting GPX4 also promote ferroptosis in some malignant tumor cells such as pancreatic ductal adenocarcinoma (Dai et al., 2020) and colorectal cancer cells (Sui et al., 2018), etc. However, as early as the 1996 study by Imai et al. revealed that GPX4 overexpression prevents basophilic leukemia cells in mice from death caused by oxidative damage (Imai et al., 1996), thus, theoretically, GPX4 overexpression could make cells resistant to oxidative stress-induced ferroptosis.