It was recently pointed out that the anti-oncogene BRCA1-Associated Protein 1 (BAP1) deubiquitinates the H2Aub portion of the SLC7A11 gene promoter and represses SLC7A11 expression, thereby limiting Cys uptake and increasing ferroptosis sensitivity; on the contrary, the lack of BAP1 in cancer cells leads to SLC7A11 upregulation and ferroptosis resistance (Zhang et al., 2018). The gene discussed is BAP1; the disease is cancer.