The inhibition of Sirtuins 6 (SIRT6), a member of the Sirtuin family of NAD (+)-dependent enzymes, lead to the inactivation of the Keap1/Nrf2 signalling pathway and downregulation of GPX4, which overcomes sorafenib resistance by promoting ferroptosis in gastric cancer (Cai et al., 2021). The gene discussed is GPX4; the disease is gastric cancer.