Nrf2 upregulates the expression and activity of SLC7A11 in breast cancer cells during oxidative stress, and promotes the survival of breast cancer cells from drugs and other treatments by antagonizing ROS, while Nrf2 expression is downregulated when ROS levels are reduced (Habib et al., 2015; Mostafavi-Pour et al., 2017). The gene discussed is NFE2L2; the disease is breast cancer.