In vitro, β-elemene (a ferroptosis inducer) in combination with cetuximab was shown to induce iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of GPX4, SLC7A11 and other negative regulatory proteins in KRAS mutant CRC cells (Chen P. et al., 2020). The gene discussed is GPX4; the disease is colorectal carcinoma.