SLC7A11 overexpression promote lung cancer cell metastasis and proliferation in vivo and in vitro by mediating cellular uptake of cysteine and reducing ROS production; conversely, SLC7A11 downregulation lead to ferroptosis (Liu et al., 2020; Chen M. et al., 2021).Meanwhile, lung cancer cell also developed ferroptosis resistance by some mechanisms to enhance the expression of SLC7A11. The gene discussed is SLC7A11; the disease is lung cancer.