Chrysophanol has been shown to promote MKN28 gastric cancer cell pyroptosis via NLRP3/Caspase1/GSDMD, and the Caspase1 inhibitor VX765 can reduce the chrysophanol-induced pyroptosis of MKN28 gastric cancer cells (Min et al., 2021). The gene discussed is GSDMD; the disease is gastric cancer.