A recent study provided strong evidence that phosphatase and tensin homolog (PTEN)-induced kinase 1/(PINK1)/mitotic fusion 2 (MFN2)/Parkin–mediated mitotic phagocytosis of macrophages is downregulated during renal fibrosis, and deletion of PINK1 or Parkin promotes the progression of macrophages to mitotic/M2 macrophages, which favors renal fibrosis (Bhatia et al., 2019). Here, PTEN is linked to renal fibrosis.