In exploring the antifibrotic effects of G-Rb1 in the G-Rb1 UUO mice model, it has been shown that G-Rb1 reverses UUO-induced p62 downregulation, LC3 upregulation, and LC3 I/II ratio, suggesting that G-Rb1 inhibits UUO-induced autophagy activation and thus attenuates renal fibrosis (Liu et al., 2020). The gene discussed is PIK3R1; the disease is renal fibrosis.