AKT1 and autoimmune thyroid disease: KEGG functional annotation analysis (Figure 4A) showed that cytokine receptor interaction, neural activity ligand–receptor interaction, Rap1 signaling pathway, autoimmune thyroid disease, natural killer cell-mediated cytotoxicity, PI3K-Akt signaling pathway, gap junction, calcium signaling pathway, and oxytocin signaling pathway were up-regulated.