NDC80 and Familial prostate cancer: Furthermore, the turnover of NDC80 is indispensable for maintaining the conditions necessary for meiosis, in which the loss of phosphorylation of NDC80 at ser-55 and ser-69 causes an erroneous kinetochore-microtubule interaction in colon, lung, and prostate cancers (Chen et al., 2020; Iemura et al., 2021).