SMAD3 and renal fibrosis: Whether JPYSF plays a role in alleviating renal fibrosis via targeting miR-192-5p to inhibit the activation of TGF-β/Smad3 signaling and JPYSF keeps renal handling of fluid balance by targeting miR-192-5p to modulate Na+/K + -ATPase through in CKD warrants further exploration.